dr. brendan d. manning

professor of genetics and complex diseases

harvard university

Dr. Brendan Manning is a Professor in the Department of Genetics and Complex Diseases at Harvard University’s T.H. Chan School of Public Health, Director of the PhD Program in Biological Sciences in Public Health at Harvard’s Graduate School of Arts and Sciences, and a Faculty Member of the Dana-Farber/Harvard Cancer Center. Dr. Manning received his BS from the University of Massachusetts, Amherst and his PhD from Yale University. He then joined the laboratory of Lewis Cantley at Harvard Medical School for his postdoctoral research. During this time, he discovered that the tuberous sclerosis complex (TSC) tumor suppressors serve as the molecular connection between the PI3K and mTOR pathways, thereby linking a signaling pathway activated in the majority of human cancers to a nutrient-sensing pathway that controls cell growth and metabolism. His own laboratory at Harvard is focused on the PI3K-mTOR signaling network at the interface of cancer, aging, and metabolism. Among other honors, Dr. Manning is an inaugural recipient of the National Cancer Institute’s Outstanding Investigator Award.